Perfadex®

Perfadex®

The Gold Standard in Lung Preservation

Description

Perfadex® is a colloid based “extracellular” low potassium electrolyte solution for rapid cooling, perfusion and storage of lungs in connection with transplantation.

Clinical Pharmacology

When used as directed, after organ removal from the donor. Administration of the solution at the recommended temperatures will effectively cool the organ, to reduce its metabolic requirements.

Indications and Usage

Perfadex® Solution for Lung perfusion is indicated for the flushing, storage and transportation of isolated lungs after removal from the donor, in preparation for eventual transplantation into a recipient.

Composition

Each 1,000 ml Perfadex® contains 5% dextran 40 (Mw 40.000), Na138 mmol, K+ 6 mmol, Mg 2+ 0.8 mmol, Cl– 142 mmol, SO 4 2- 0.8 mmol, H2PO 4-plus HPO4 2-0.8 mmol and glucose 5 mmol.

Additives

At about pH 5.5, shelf-life is 3 years. Adjust to about pH 7.4 shortly before use by addition of 1 mmol THAM/TRIS (trometamol or tromethamine) per litre Perfadex®. The solution should then be chilled and used within 24 hours.

Contraindications

There are no known contraindications when used as directed.

Warnings

Do not use if contamination is evident in the solution. Use only clear solutions and undamaged containers. Maintain aseptic technique when making the recommended additions as well as during administration.

NOT INTENDED FOR DIRECT INJECTION OR INTRAVENOUS INFUSION.

Precautions

Chill solution as directed prior to making the recommended additions.

Make additions and mix thoroughly immediately prior to use.

Mixed solution should be kept chilled and used within 24 Hours.

How supplied

Perfadex® is supplied in 1,000 mL or 2,800 mL (PVC bags).

Storage

Perfadex®  solution should be stored below 30ºC.

Do not freeze.

Shelf life

The Shelf life of Perfadex® solution is 3 years.

 

Leave a Reply

Your email address will not be published. Required fields are marked *